What steps can be taken to enhance in-situ resource utilization (ISRU) for future astronauts on Mars? This is what a recent study presented at the 56th Lunar and Planetary Science Conference hopes to address as an international team of researchers investigated the reasons, benefits, and challenges of conducting ISRU on Mars. This study has the potential to help astronauts, scientists, engineers, and mission planners develop new methods for enhancing the survivability of future Mars astronauts while also maximizing mission success.