Hopefully, were about to travel back to the Moon relatively soon. And while the original giant leap for mankind was taken by a human, Neil Armstrong brought a plethora of other forms of life along with him. Humans themselves are essentially walking ecosystems, and understanding how our microbial companions survive in the harsh environments of space will be critical to ensure the health and safety of future astronauts, no matter where their giant leaps might be. A new PhD thesis from Tommaso Zaccaria at Radboud University showcases just how well-suited to some of these harsh environments terrestrial pathogens actually are.