What is RE9 Insanity mode? We love a challenge, but Requiem's hardest difficulty mode can test the most seasoned zombie slayer. Between tough enemies that take entire clips of ammo to take down, plus a restrictive save system, a successful playthrough on Insanity mode requires a ton of preparation. If you're familiar with the Madhouse or Nightmare modes of earlier horror games, you'll already have some idea of what awaits you in Resident Evil Requiem's tough-as-nails difficulty mode. Whether you're new to the challenge or shooting for a new speedrun record, we've got a full list of all Insanity mode differences to help you avoid a nasty surprise.