What are all the Ascension levels in Slay the Spire 2? Upon completing the game for the first time, you unlock Ascension levels - difficulty modifiers that introduce challenging mechanics. Each Ascension level offers a new way to hinder you, and the effects stack as you progress through the levels. The number of Ascension levels varies depending on how far you've managed to progress as each of the Slay the Spire 2 characters. For example, if you've completed the card game several times as The Regent, your unlocked Ascension levels are tied to that specific character, meaning you'll need to complete the same feat across all the heroes.